(Full text is available at http://www.manu.edu.mk/prilozi). BACKGROUND. Hp inhabits the stomach of more than 50% of humans and is the most frequent cause of chronic gastritis worldwide. The purpose of this research has been to present the importance of combining topographical, morphological and etiological information of diagnostic evaluation on grading gastritis in our material according to the Updated Sydney Classification, as well as to represent the frequency and the evaluation of Hp gastritis after eradication in order to prevent the development of gastric cancer. MATERIALS AND METHODS. 154 cases of gastric mucosa (endoscopic biopsies) which were fixed in buffered neutral formalin and embedded in paraffin were invwstigated. Tissue sections (5microm thick) were cut and stained with H&E, May Grunwald Giemsa and Silver stain. The biopsy cases were analysed in an attempt to assess the major histopathological features of gastritis. The histopathological major variables were graded on a scale of 3 (mild, moderate and severe). RESULTS. There were 36 (23.37%) cases positive for Hp (22.2%, 72.2%, 5.5%). Atrophy was positive in 23 (14.93%) cases with the scale (47.8%; 47.8%; 4.34%). Dysplasia was positive in 13 (8.44%) cases with the scale (84.6%; 7.6%; 7.6%). Intestinal metaplasia was positive in 25 (16.2%) with the scale (76%; 20%, 4%). There were 6 (3.8%) cases of MZL, which were treated appropriately. CONCLUSIONS. Our data indicate the importannce of early eradication of Helicobacter pylori in order to prevent the eventual development of gastric cancer. These findings should influence the treatment of gastric cancers. Key words: Updated Sydney System of Classification, Hp gastritis, morphology.