Luteinizing hormone increases platelet-derived growth factor-D gene expression in human granulosa-luteal cells

Yuh-Ming Hwu; Sheng-Hsiang Li; Robert Kuo-kuang Lee; Ming-Huei Lin; Yu-Hui Tsai; Tien-Shun Yeh

doi:10.1016/j.fertnstert.2009.05.064

Luteinizing hormone increases platelet-derived growth factor-D gene expression in human granulosa-luteal cells

Fertil Steril. 2009 Dec;92(6):2065-8. doi: 10.1016/j.fertnstert.2009.05.064. Epub 2009 Sep 5.

Authors

Yuh-Ming Hwu¹, Sheng-Hsiang Li, Robert Kuo-kuang Lee, Ming-Huei Lin, Yu-Hui Tsai, Tien-Shun Yeh

Affiliation

¹ Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan.

PMID: 19733850
DOI: 10.1016/j.fertnstert.2009.05.064

Abstract

We aimed to investigate the effects of LH and FSH on the gene expression of the platelet-derived growth factor (PDGF) gene family in human granulosa-luteal cells. We found that LH significantly increased PDGF-D messenger RNA (mRNA) expression but suppressed PDGF-B and PDGF-C mRNA in human granulosa-luteal cells, and FSH also increases PDGF-D gene expression, but to a lesser extent.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cells, Cultured
Corpus Luteum / cytology*
Female
Gene Expression / drug effects
Granulosa Cells / drug effects
Granulosa Cells / metabolism*
Humans
Luteinizing Hormone / metabolism*
Luteinizing Hormone / pharmacology
Lymphokines / genetics*
Ovarian Follicle / cytology
Platelet-Derived Growth Factor / genetics*
Proto-Oncogene Proteins c-sis / genetics
RNA, Messenger / metabolism

Substances

Lymphokines
PDGFD protein, human
Platelet-Derived Growth Factor
Proto-Oncogene Proteins c-sis
RNA, Messenger
platelet-derived growth factor C
Luteinizing Hormone