Synthesis and antifungal activity of benzo[d]oxazole-4,7-diones

Chung-Kyu Ryu; Ra-Young Lee; Na Young Kim; Yang Hui Kim; Ae Li Song

doi:10.1016/j.bmcl.2009.08.062

Synthesis and antifungal activity of benzo[d]oxazole-4,7-diones

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5924-6. doi: 10.1016/j.bmcl.2009.08.062. Epub 2009 Aug 21.

Authors

Chung-Kyu Ryu¹, Ra-Young Lee, Na Young Kim, Yang Hui Kim, Ae Li Song

Affiliation

¹ College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea. ckryu@ewha.ac.kr

PMID: 19733068
DOI: 10.1016/j.bmcl.2009.08.062

Abstract

Benzo[d]oxazole-4,7-diones were synthesized and tested for in vitro antifungal activity against fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that benzo[d]oxazole-4,7-diones would be potent antifungal agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis*
Antifungal Agents / chemistry
Antifungal Agents / pharmacology
Fungi / drug effects
Microbial Sensitivity Tests
Oxazoles / chemical synthesis*
Oxazoles / chemistry
Oxazoles / pharmacology
Structure-Activity Relationship

Substances

Antifungal Agents
Oxazoles