Polymyxin B and colistimethate are comparable as to efficacy and renal toxicity

Maura S Oliveira; Gladys V B Prado; Silvia F Costa; Renato S Grinbaum; Anna S Levin

doi:10.1016/j.diagmicrobio.2009.07.018

Polymyxin B and colistimethate are comparable as to efficacy and renal toxicity

Diagn Microbiol Infect Dis. 2009 Dec;65(4):431-4. doi: 10.1016/j.diagmicrobio.2009.07.018. Epub 2009 Sep 3.

Authors

Maura S Oliveira¹, Gladys V B Prado, Silvia F Costa, Renato S Grinbaum, Anna S Levin

Affiliation

¹ Department of Infection Control of Hospital das Clínicas, Rua Dr. Ovídio Pires de Campos, São Paulo-SP 05403-010, Brazil.

PMID: 19733029
DOI: 10.1016/j.diagmicrobio.2009.07.018

Abstract

We compared 41 patients who received colistimethate with 41 who received polymyxin B for the treatment of serious infections caused by carbapenem-resistant Acinetobacter spp. and found both polymyxins have similar efficacy and toxicity.

MeSH terms

Acinetobacter Infections / drug therapy*
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents / adverse effects
Anti-Bacterial Agents / therapeutic use
Child
Colistin / adverse effects
Colistin / analogs & derivatives*
Colistin / therapeutic use
Female
Humans
Kidney / drug effects*
Male
Middle Aged
Polymyxin B / adverse effects*
Polymyxin B / therapeutic use*
Treatment Outcome
Young Adult

Substances

Anti-Bacterial Agents
colistinmethanesulfonic acid
Polymyxin B
Colistin