Abstract
A new 2-arylbenzofuran derivative (diptoindonesin G) (1), along with nine known oligostilbenes, have been isolated and identified from the acetone extract of the tree bark of Hopea mengarawan. The structures of these compounds were determined based on spectroscopic data, including 2D NMR and HREIMS spectra. On cytotoxic evaluation of the isolated compounds against murin leukemia P-388 cells, compound 1 was the strongest in inhibiting the growth of the cells.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Benzofurans / chemistry*
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Benzofurans / isolation & purification
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Benzofurans / pharmacology*
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Cell Line, Tumor
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Dipterocarpaceae / chemistry*
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Drug Screening Assays, Antitumor
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Leukemia P388 / drug therapy
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Magnetic Resonance Spectroscopy
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Mice
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Plant Bark / chemistry
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Solvents
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Spectroscopy, Fourier Transform Infrared
Substances
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Antineoplastic Agents, Phytogenic
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Benzofurans
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Solvents
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diptoindonesin G