Coumestan glycosides from the stem bark of Cylicodiscus gabunensis

Nat Prod Commun. 2009 Jul;4(7):931-4.

Abstract

Two new coumestan glycosides, coumestoside C (1) and coumestoside D (2), were isolated from the stem bark of Cylicodiscus gabunensis Harms. Their structures were established by spectroscopic means and chemical transformations as 9-O-alpha-L-rhamnopyranosyl-3-hydroxy-4-(5'-hydroxy-3'-methylbut-2'E-enyl) coumestan (1) and 9-O-beta-D-galactopyranosyl-3-O- prenyl-4-hydroxycoumestan. Coumestoside C exhibited antimicrobial activity against Proteus vulgaris.

MeSH terms

  • Carbohydrates / chemistry
  • Coumarins / chemistry*
  • Coumarins / isolation & purification
  • Coumarins / pharmacology
  • Fabaceae / chemistry*
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Hydrolysis
  • Microbial Sensitivity Tests
  • Plant Bark / chemistry
  • Plant Extracts / chemistry
  • Plant Stems / chemistry
  • Proteus vulgaris / drug effects
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Carbohydrates
  • Coumarins
  • Glycosides
  • Plant Extracts
  • coumestan