Abstract
Two new coumestan glycosides, coumestoside C (1) and coumestoside D (2), were isolated from the stem bark of Cylicodiscus gabunensis Harms. Their structures were established by spectroscopic means and chemical transformations as 9-O-alpha-L-rhamnopyranosyl-3-hydroxy-4-(5'-hydroxy-3'-methylbut-2'E-enyl) coumestan (1) and 9-O-beta-D-galactopyranosyl-3-O- prenyl-4-hydroxycoumestan. Coumestoside C exhibited antimicrobial activity against Proteus vulgaris.
MeSH terms
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Carbohydrates / chemistry
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Coumarins / chemistry*
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Coumarins / isolation & purification
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Coumarins / pharmacology
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Fabaceae / chemistry*
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Glycosides / chemistry*
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Glycosides / isolation & purification
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Hydrolysis
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Microbial Sensitivity Tests
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Plant Bark / chemistry
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Plant Extracts / chemistry
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Plant Stems / chemistry
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Proteus vulgaris / drug effects
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
Substances
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Carbohydrates
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Coumarins
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Glycosides
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Plant Extracts
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coumestan