In the mixed-metal complex catena-poly[bis[diaquasilver(I)] [bis[aquacopper(II)]-mu(3)-pyridine-2,5-dicarboxylato-2':1:1'kappa(5)N,O(2):O(5):O(5),O(5')-mu-pyridine-2,5-dicarboxylato-2:1kappa(4)N,O(2):O(5),O(5')-disilver(I)-mu(3)-pyridine-2,5-dicarboxylato-1:1':2''kappa(5)O(5),O(5'):O(5):N,O(2)-mu-pyridine-2,5-dicarboxylato-1':2'''kappa(4)O(5),O(5'):N,O(2)] hexahydrate], {[Ag(H(2)O)(2)][AgCu(C(7)H(3)NO(4))(2)(H(2)O)].3H(2)O}(n), a square-pyramidal Cu(II) center is coordinated by two N atoms and two O atoms from two pyridine-2,5-dicarboxylate (2,5-pydc) ligands and a water molecule, forming a [Cu(2,5-pydc)(2)(H(2)O)](2-) metalloligand. One Ag(I) center is coordinated by five O atoms from three 2,5-pydc ligands and, as a result, the [Cu(2,5-pydc)(2)(H(2)O)](2-) metalloligands act as linkers in a unique mu(3)-mode connecting Ag(I) centers into a one-dimensional anionic double chain along the [101] direction. The other Ag(I) center is coordinated by two water molecules, forming an [Ag(H(2)O)(2)](+) cation. Four adjacent Ag(I) centers are associated by Ag...Ag interactions [3.126 (1) and 3.118 (1) A], producing a Z-shaped Ag(4) unit along the [010] direction and connecting the anionic chains into a two-dimensional layer structure. This study offers information for engineering mixed-metal complexes based on copper(II)-pyridinedicarboxylate metalloligands.