Abstract
Three small compound biaryl libraries featuring a novel fluorinating cleavage strategy for preparation of a difluoromethyl group were assembled on solid supports. The average reaction yield per step was up to 96% in a synthetic sequence over five to six steps. Key features were Suzuki coupling reactions, transesterification with potassium cyanide and amidation reaction with trimethyl aluminum on solid supports.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Combinatorial Chemistry Techniques / methods*
-
Hydrocarbons, Fluorinated / chemical synthesis*
-
Hydrocarbons, Fluorinated / chemistry
-
Molecular Structure
-
Quinolizines / chemistry*
-
Small Molecule Libraries*
-
Stereoisomerism
-
Sulfur Compounds / chemistry*
Substances
-
Hydrocarbons, Fluorinated
-
Quinolizines
-
Small Molecule Libraries
-
Sulfur Compounds
-
dithiane