[Current status and perspective of heavy ion beam therapy for patients with pelvic recurrence after primarily resected rectal cancer]

Shigeru Yamada; Makoto Shinoto; Yasuda Shigeo; Hiroshi Imada; Hirotoshi Kato; Tadashi Kamada; Hirohiko Tsujii

[Current status and perspective of heavy ion beam therapy for patients with pelvic recurrence after primarily resected rectal cancer]

Gan To Kagaku Ryoho. 2009 Aug;36(8):1263-6.

[Article in Japanese]

Authors

Shigeru Yamada¹, Makoto Shinoto, Yasuda Shigeo, Hiroshi Imada, Hirotoshi Kato, Tadashi Kamada, Hirohiko Tsujii

Affiliation

¹ National Institute of Radiological Sciences, Research Center for Charged Particle Therapy, Inage-ku, Chiba, Japan.

PMID: 19718862

Abstract

Purpose: To evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with locally recurrent rectal cancer.

Patients and methods: We conducted a phase I / II dose escalation of carbon ion radiotherapy. One hundred twelve patients with 117 sites of locally recurrent cancer receiving carbon ion radiotherapy were analyzed.

Results: None of 112 patients experienced National Cancer Institute-Common Toxicity Criteria grade 3 to 5 acute reactions. The local control rate in patients treated with 67.2 GyE, 70.4 GyE and 73.6 GyE in the present study was 70%, 89% and 97% at 5 years, respectively. The overall survival rates in patients treated with 73.6 GyE were 72% at 3 years and 40% at 5 years.

Conclusion: Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally recurrent rectal cancer, providing good local control and offering a survival advantage without unacceptable morbidity.

Publication types

Case Reports
Clinical Trial, Phase I
Clinical Trial, Phase II

MeSH terms

Adult
Aged
Female
Heavy Ion Radiotherapy*
Humans
Middle Aged
Neoplasm Recurrence, Local / radiotherapy
Pelvic Neoplasms / mortality
Pelvic Neoplasms / radiotherapy*
Pelvic Neoplasms / secondary
Rectal Neoplasms / pathology*
Rectal Neoplasms / surgery*