Delayed graft function is reduced with antithymocyte globulin induction in pediatric kidney transplantation

Transplant Proc. 2009 Jul-Aug;41(6):2373-5. doi: 10.1016/j.transproceed.2009.06.037.

Abstract

Reduction of delayed graft function (DGF) is critical to the success of renal transplantation. We report graft outcomes with antithymocyte globulin (ATG) induction compared with using interleukin-2 receptor antagonist basiliximab (IL-2RA). Twelve pediatric patients received a pediatric deceased donor kidney. We treated them with ATG (group A, ATG; n = 6) or IL-2RA (group B, n = 6). DGF was observed in 0 cases (group A) and in 6 cases (group B), which showed a mean of 7 +/- 3 days (P < .001). In group A, lymphopenia occurred routinely resolving after 3-6 months, none with serious infection. The incidence of opportunistic infections was 0% in both groups. One-year patient and graft survivals were 100% in both groups. ATG induction significantly reduced the incidence of delayed graft function. Both induction treatments led to a good patient and graft survival.

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • Antilymphocyte Serum / immunology*
  • Antilymphocyte Serum / therapeutic use*
  • Basiliximab
  • Cadaver
  • Child
  • Child, Preschool
  • Delayed Graft Function / immunology*
  • Dose-Response Relationship, Drug
  • Female
  • Graft Survival / immunology*
  • Histocompatibility Testing
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Infant
  • Kidney Diseases / classification
  • Kidney Diseases / surgery
  • Kidney Transplantation / immunology*
  • Male
  • Recombinant Fusion Proteins / therapeutic use
  • Retrospective Studies
  • Tacrolimus / therapeutic use
  • Tissue Donors

Substances

  • Antibodies, Monoclonal
  • Antilymphocyte Serum
  • Immunosuppressive Agents
  • Recombinant Fusion Proteins
  • Basiliximab
  • Tacrolimus