Synthesis and cytotoxicity studies of new cryptophycin analogues

Arch Pharm (Weinheim). 2009 Oct;342(10):577-83. doi: 10.1002/ardp.200900067.

Abstract

Two analogues of cryptophycin were synthesized and biologically evaluated for their in-vitro cytotoxicities against several solid tumors and leukemia cell lines. The results revealed that both analogues exhibited a broad range of cytotoxic activity with observed IC(50 )values in the muM-range, and compound 4 was more effective than compound 3 in most assays studied.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects*
  • Cell Survival / drug effects
  • Depsipeptides / chemical synthesis
  • Depsipeptides / pharmacology*
  • Dose-Response Relationship, Drug
  • Humans
  • Inhibitory Concentration 50
  • Mice
  • Molecular Structure
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Depsipeptides
  • cryptophycin