Abstract
Two analogues of cryptophycin were synthesized and biologically evaluated for their in-vitro cytotoxicities against several solid tumors and leukemia cell lines. The results revealed that both analogues exhibited a broad range of cytotoxic activity with observed IC(50 )values in the muM-range, and compound 4 was more effective than compound 3 in most assays studied.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects*
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Cell Survival / drug effects
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Depsipeptides / chemical synthesis
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Depsipeptides / pharmacology*
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Dose-Response Relationship, Drug
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Humans
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Inhibitory Concentration 50
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Mice
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Molecular Structure
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Depsipeptides
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cryptophycin