Shape and release control of a peptide decorated vesicle through pH sensitive orthogonal supramolecular interactions

Frank Versluis; Itsuro Tomatsu; Seda Kehr; Carlo Fregonese; Armand W J W Tepper; Marc C A Stuart; Bart Jan Ravoo; Roman I Koning; Alexander Kros

doi:10.1021/ja9026264

Shape and release control of a peptide decorated vesicle through pH sensitive orthogonal supramolecular interactions

J Am Chem Soc. 2009 Sep 23;131(37):13186-7. doi: 10.1021/ja9026264.

Authors

Frank Versluis¹, Itsuro Tomatsu, Seda Kehr, Carlo Fregonese, Armand W J W Tepper, Marc C A Stuart, Bart Jan Ravoo, Roman I Koning, Alexander Kros

Affiliation

¹ Leiden Institute of Chemistry, University Leiden, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.

PMID: 19711889
DOI: 10.1021/ja9026264

Abstract

A pH sensitive carrier is obtained by coating a cyclodextrin vesicle with an adamantane-terminated octapeptide through the formation of an inclusion complex. Upon lowering the pH from 7.4 to 5.0, the formation of peptide beta-sheets on the vesicle surface induces a transition of the bilayer from a sphere to a fiber. This transition is fully reversible and repeatable. The vesicles release their cargo upon fiber formation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Circular Dichroism
Cyclodextrins / chemistry
Fluorescent Dyes / chemistry
Hydrogen-Ion Concentration
Membranes, Artificial*
Oligopeptides / chemistry*
Protein Structure, Secondary
Surface Properties

Substances

Cyclodextrins
Fluorescent Dyes
Membranes, Artificial
Oligopeptides