Direct synthesis of medium-bridged twisted amides via a transannular cyclization strategy

Org Lett. 2009 Sep 3;11(17):3878-81. doi: 10.1021/ol901449y.

Abstract

The sequential RCM to construct a challenging medium-sized ring followed by a transannular cyclization across a medium-sized ring delivers previously unattainable twisted amides from simple acyclic precursors.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amides / chemical synthesis*
  • Amides / chemistry
  • Catalysis
  • Cyclization
  • Heterocyclic Compounds, Bridged-Ring / chemical synthesis*
  • Heterocyclic Compounds, Bridged-Ring / chemistry
  • Molecular Structure

Substances

  • Amides
  • Heterocyclic Compounds, Bridged-Ring