Abstract
A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of Thapsia villosa var. villosa L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca(2+)-dependent ATPases (SERCA) pump. Compounds 9, 10 and 11 increased significantly the cytoplasmic free calcium concentration ([Ca(2+)](c)) in human platelets in a concentration-dependent manner.
Georg Thieme Verlag KG Stuttgart-New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Blood Platelets / metabolism*
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Calcium / blood*
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Calcium-Transporting ATPases / antagonists & inhibitors*
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Dose-Response Relationship, Drug
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Heterocyclic Compounds, 3-Ring / isolation & purification
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Heterocyclic Compounds, 3-Ring / pharmacology
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Humans
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Lactones / isolation & purification
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Lactones / pharmacology
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Molecular Structure
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Roots
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Propanols / chemistry
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Propanols / isolation & purification
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
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Sesquiterpenes, Germacrane / chemistry
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Sesquiterpenes, Germacrane / isolation & purification
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Sesquiterpenes, Germacrane / pharmacology
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Sesquiterpenes, Guaiane / isolation & purification
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Sesquiterpenes, Guaiane / pharmacology
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Sulfhydryl Compounds / isolation & purification
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Sulfur
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Thapsia / chemistry*
Substances
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2,10,11-triacetoxy-8-(3-methyltiopropanoyloxy)slov-3-enolide
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Enzyme Inhibitors
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Heterocyclic Compounds, 3-Ring
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Lactones
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Plant Extracts
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Propanols
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Sesquiterpenes
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Sesquiterpenes, Germacrane
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Sesquiterpenes, Guaiane
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Sulfhydryl Compounds
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thapsitranstagin
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1-phenylpropanol
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Sulfur
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Calcium-Transporting ATPases
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Calcium