Fluoride protects boronic acids in the copper(I)-mediated click reaction

Chem Commun (Camb). 2009 Sep 21:(35):5251-3. doi: 10.1039/b909575f. Epub 2009 Aug 6.

Abstract

Fluoride has been found to protect boronic acids from copper(i)-mediated decomposition; such findings should be very useful for the preparation of boronic acid-based carbohydrate sensors and boronic acid conjugates using the copper(i)-mediated click reaction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boronic Acids / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Fluorides / chemistry*
  • Triazoles / chemical synthesis
  • Triazoles / chemistry

Substances

  • Boronic Acids
  • Triazoles
  • Copper
  • Fluorides