Abstract
A series of triterpene endoperoxides was synthesized and screened for antitumor activity in a panel of 15 human cancer cell lines by a sulforhodamine-B (SRB) assay. The compounds induce apoptosis and show excellent antitumor activity.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects*
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Cell Line, Tumor
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Peroxides / chemical synthesis
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Peroxides / pharmacology*
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Structure-Activity Relationship
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Triterpenes / chemical synthesis
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Triterpenes / pharmacology*
Substances
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Antineoplastic Agents
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Peroxides
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Triterpenes