Antitumoractive endoperoxides from triterpenes

Arch Pharm (Weinheim). 2009 Oct;342(10):569-76. doi: 10.1002/ardp.200900051.

Abstract

A series of triterpene endoperoxides was synthesized and screened for antitumor activity in a panel of 15 human cancer cell lines by a sulforhodamine-B (SRB) assay. The compounds induce apoptosis and show excellent antitumor activity.

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Peroxides / chemical synthesis
  • Peroxides / pharmacology*
  • Structure-Activity Relationship
  • Triterpenes / chemical synthesis
  • Triterpenes / pharmacology*

Substances

  • Antineoplastic Agents
  • Peroxides
  • Triterpenes