Abstract
Impaired wound healing in diabetics is due to pathologic angiogenesis, which is a result of aberrant sphingosine-1-phosphate signaling. Pharmacologic modulation of sphingosine-1-phosphate-dependent signaling normalizes healing in diabetic wounds.
Copyright 2010 Mosby, Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Diabetes Complications / etiology*
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Diabetes Complications / physiopathology
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Diabetes Complications / prevention & control*
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Humans
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Lysophospholipids / physiology*
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Skin Ulcer / etiology*
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Skin Ulcer / physiopathology
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Skin Ulcer / prevention & control*
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Sphingosine / analogs & derivatives*
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Sphingosine / physiology
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Wound Healing / physiology*
Substances
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Lysophospholipids
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sphingosine 1-phosphate
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Sphingosine