Normalization of diabetic wound healing

Surgery. 2010 Mar;147(3):446-9. doi: 10.1016/j.surg.2009.04.038. Epub 2009 Aug 22.

Abstract

Impaired wound healing in diabetics is due to pathologic angiogenesis, which is a result of aberrant sphingosine-1-phosphate signaling. Pharmacologic modulation of sphingosine-1-phosphate-dependent signaling normalizes healing in diabetic wounds.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Diabetes Complications / etiology*
  • Diabetes Complications / physiopathology
  • Diabetes Complications / prevention & control*
  • Humans
  • Lysophospholipids / physiology*
  • Skin Ulcer / etiology*
  • Skin Ulcer / physiopathology
  • Skin Ulcer / prevention & control*
  • Sphingosine / analogs & derivatives*
  • Sphingosine / physiology
  • Wound Healing / physiology*

Substances

  • Lysophospholipids
  • sphingosine 1-phosphate
  • Sphingosine