The emerging role of microRNAs in immune cell development and differentiation

APMIS. 2009 Sep;117(9):635-43. doi: 10.1111/j.1600-0463.2009.02520.x.

Abstract

MicroRNAs (miRNAs) are small RNA strands (20-25 nucleotides) that regulate gene expression by translational repression as well as by messenger RNA degradation. This review will examine the application and function of miRNAs in immune cell development and differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / cytology
  • B-Lymphocytes / immunology
  • Cell Differentiation
  • Gene Expression
  • Hematopoiesis / genetics
  • Hematopoiesis / immunology
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics
  • Leukemia, Lymphocytic, Chronic, B-Cell / immunology
  • Lymphoma, T-Cell / genetics
  • Lymphoma, T-Cell / immunology
  • MicroRNAs / genetics
  • MicroRNAs / immunology*
  • Monocytes / cytology
  • Monocytes / immunology
  • Neoplasms / genetics
  • Neoplasms / immunology
  • RNA, Neoplasm / genetics
  • RNA, Neoplasm / immunology
  • Ribonuclease III / metabolism
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology

Substances

  • MicroRNAs
  • RNA, Neoplasm
  • Ribonuclease III