Role of guanidine group at the N-terminal proctolin chain in cardioexcitatory effects in insects

Int J Pept Protein Res. 1990 Jan;35(1):12-6. doi: 10.1111/j.1399-3011.1990.tb00715.x.

Abstract

Six proctolin analogues (I-VI) modified in position 1 of the peptide chain by the following amino acids: homo-Arg, Gac, Gav, Gap, Phe (p-guanidino) and Orn, were synthesized by conventional liquid phase method. The myotropic activity of the obtained peptides was investigated in cardioexcitatory test on two insect species, cockroach, Periplaneta americana L., and yellow mealworm, Tenebrio molitor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chemical Phenomena
  • Chemistry
  • Cockroaches / drug effects
  • Guanidines / pharmacology*
  • Heart Rate / drug effects*
  • Insecta / drug effects*
  • Neuropeptides*
  • Neurotransmitter Agents / pharmacology*
  • Oligopeptides / pharmacology*
  • Peptide Mapping
  • Stimulation, Chemical
  • Tenebrio / drug effects

Substances

  • Guanidines
  • Neuropeptides
  • Neurotransmitter Agents
  • Oligopeptides
  • proctolin