Abstract
Six proctolin analogues (I-VI) modified in position 1 of the peptide chain by the following amino acids: homo-Arg, Gac, Gav, Gap, Phe (p-guanidino) and Orn, were synthesized by conventional liquid phase method. The myotropic activity of the obtained peptides was investigated in cardioexcitatory test on two insect species, cockroach, Periplaneta americana L., and yellow mealworm, Tenebrio molitor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chemical Phenomena
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Chemistry
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Cockroaches / drug effects
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Guanidines / pharmacology*
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Heart Rate / drug effects*
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Insecta / drug effects*
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Neuropeptides*
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Neurotransmitter Agents / pharmacology*
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Oligopeptides / pharmacology*
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Peptide Mapping
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Stimulation, Chemical
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Tenebrio / drug effects
Substances
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Guanidines
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Neuropeptides
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Neurotransmitter Agents
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Oligopeptides
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proctolin