Abstract
While promiscuous expression of tissue-specific antigens (TSAs) in the thymus is essential for self-tolerance, immunologically relevant TSA expression may also occur in the secondary lymphoid organs. A new study links the transcriptional regulator Deaf1 with altered TSA expression in the secondary lymphoid organs and autoimmune diabetes.
MeSH terms
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AIRE Protein
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Animals
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CD8-Positive T-Lymphocytes / immunology
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DNA-Binding Proteins
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Diabetes Mellitus, Type 1 / etiology*
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Lymph Nodes / immunology*
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Mice
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Mice, Inbred NOD
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Nuclear Proteins / physiology*
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Pancreas / immunology*
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Self Tolerance
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Transcription Factors / physiology
Substances
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DEAF1 protein, human
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DNA-Binding Proteins
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Nuclear Proteins
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Transcription Factors