Does frank diabetes in first-degree relatives of a pregnant woman affect the likelihood of her developing gestational diabetes mellitus or nongestational diabetes?

Am J Obstet Gynecol. 2009 Dec;201(6):576.e1-6. doi: 10.1016/j.ajog.2009.06.069. Epub 2009 Aug 18.

Abstract

Objective: We sought to examine the associations between patterns of family histories of diabetes and a history of gestational diabetes mellitus (hGDM).

Study design: Parous women participating in the National Health and Nutrition Examination Survey III (n=4566) were classified as having hGDM only, diagnosed diabetes, or neither. Family history of diabetes was categorized as: maternal only, paternal only, biparental, and sibling only. The covariate-adjusted prevalence and odds of having hGDM were estimated.

Results: Compared to women without a family history of diabetes, women with a maternal (odds ratio [OR], 3.0; 95% confidence interval [CI], 1.2-7.3), paternal (OR, 3.3; 95% CI, 1.1-10.2), or sibling (OR, 7.1; 95% CI, 1.6-30.9) history of diabetes had greater odds of hGDM, after adjustment for age and race/ethnicity.

Conclusion: Women with a sibling history of diabetes were more likely to have hGDM than women with other family history patterns.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Diabetes Mellitus / genetics
  • Diabetes, Gestational / genetics*
  • Family
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Pregnancy