Brown recluse spider venom: proteomic analysis and proposal of a putative mechanism of action

Lucilene D dos Santos; Nathalia B Dias; José Roberto; A S Pinto; Mario S Palma

doi:10.2174/092986609788923383

Brown recluse spider venom: proteomic analysis and proposal of a putative mechanism of action

Protein Pept Lett. 2009;16(8):933-43. doi: 10.2174/092986609788923383.

Authors

Lucilene D dos Santos¹, Nathalia B Dias, José Roberto, A S Pinto, Mario S Palma

Affiliation

¹ Laboratory of Structural Biology and Zoochemistry, CEIS/Dept. Biology, Institute of Biosciences of Rio Claro, São Paulo State University (UNES), Rio Claro, SP, Brazil.

PMID: 19689420
DOI: 10.2174/092986609788923383

Abstract

Loxosceles intermedia spider venom was subjected to proteomic analysis through a MudPIT shot-gun approach to identify the protein composition. Were identified 39 proteins which seem to responsible by the lesion of different types of tissues, to some physiopathological actions and by the prevention of structural damage to the toxin structures.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Mass Spectrometry
Phosphoric Diester Hydrolases / analysis*
Phosphoric Diester Hydrolases / metabolism
Phosphoric Diester Hydrolases / toxicity
Proteins / analysis*
Proteins / metabolism
Proteins / toxicity
Proteome / analysis
Snake Bites / physiopathology
Spider Venoms / analysis*
Spider Venoms / metabolism
Spider Venoms / toxicity
Spiders*

Substances

Proteins
Proteome
Spider Venoms
loxosceles venom
Phosphoric Diester Hydrolases