Structural and pharmacological features of phospholipases A2 from snake venoms

Protein Pept Lett. 2009;16(8):899-907. doi: 10.2174/092986609788923365.

Abstract

Phospholipases A(2) enzymes are found in many biological sources, including snake venoms. Here we reviewed aspects of PLA(2)s including biological and structural features, interaction with binding receptors, inhibitors used on structure-function relationship studies and highlighting the mechanism of action and role of the snake venom PLA(2)s products, the lysophosphatidylcholine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Phospholipase A2 Inhibitors
  • Phospholipases A2 / chemistry*
  • Phospholipases A2 / pharmacology*
  • Sequence Alignment
  • Snake Venoms / enzymology*
  • Snakes*

Substances

  • Phospholipase A2 Inhibitors
  • Snake Venoms
  • Phospholipases A2