Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light

Opt Express. 2009 Aug 17;17(17):14780-90. doi: 10.1364/oe.17.014780.

Abstract

We present a wide-field method for obtaining three-dimensional images of turbid media. By projecting patterns of light of varying spatial frequencies on a sample, we reconstruct quantitative, depth resolved images of absorption contrast. Images are reconstructed using a fast analytic inversion formula and a novel correction to the diffusion approximation for increased accuracy near boundaries. The method provides more accurate quantification of optical absorption and higher resolution than standard diffuse reflectance measurements.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Absorption
  • Diagnostic Imaging / methods
  • Equipment Design
  • Fourier Analysis
  • Humans
  • Image Processing, Computer-Assisted
  • Light*
  • Models, Statistical
  • Nephelometry and Turbidimetry
  • Optics and Photonics*
  • Phantoms, Imaging
  • Reproducibility of Results
  • Surface Properties
  • Tomography, Optical / instrumentation*
  • Tomography, Optical / methods*