Endocytosis of lipid-anchored proteins: excluding GEECs from the crowd

J Cell Biol. 2009 Aug 24;186(4):457-9. doi: 10.1083/jcb.200907119. Epub 2009 Aug 17.

Abstract

Endocytosis of glycosylphosphatidylinositol (GPI)-linked proteins via a specific pathway into GPI-enriched early endosomal compartments (GEECs) has been proposed. How sorting into this pathway may take place is unclear. In this issue, Bhagatji et al. (2009. J. Cell Biol. doi:10.1083/jcb.200903102) provide an original mechanism for the sorting of lipid-anchored proteins that involves exclusion of bulky extracellular domains from clathrin-coated pits.

Publication types

  • Comment
  • Review

MeSH terms

  • Cell Membrane / chemistry
  • Cell Membrane / metabolism
  • Clathrin / metabolism
  • Coated Pits, Cell-Membrane / metabolism
  • Endocytosis / physiology*
  • Endosomes* / chemistry
  • Endosomes* / metabolism
  • Glycosylphosphatidylinositols / metabolism*
  • Membrane Proteins / metabolism*
  • Molecular Structure

Substances

  • Clathrin
  • Glycosylphosphatidylinositols
  • Membrane Proteins