Bakkenolides from Petasites tatewakianus

Fitoterapia. 2010 Apr;81(3):153-6. doi: 10.1016/j.fitote.2009.08.013. Epub 2009 Aug 15.

Abstract

A new bakkenolide and a known one were isolated from Petasites tatewakianus. The structure of the new compound was elucidated on the basis of spectroscopic methods including IR, EIMS, HRESIMS, 1D and 2D NMR, and the known compound was established by single crystal X-ray structural analysis. The in vitro cytotoxic activity of these two compounds against cultured human cervical carcinoma (HeLa), human breast cancer (MCF-7) and murine Lewis lung carcinoma (LLC) cell lines was also evaluated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Carcinoma / drug therapy*
  • Female
  • HeLa Cells
  • Humans
  • Mice
  • Molecular Structure
  • Neoplasms / drug therapy*
  • Petasites / chemistry*
  • Phytotherapy
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification*
  • Plant Extracts / therapeutic use
  • Rhizome
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / therapeutic use

Substances

  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • Sesquiterpenes
  • bakkenolide B
  • petatewalide A