Abstract
We report 3 cases of herpes simplex virus encephalitis in patients receiving tumor necrosis factor-alpha (TNF-alpha) inhibitors for rheumatologic disorders. Although TNF-alpha inhibitors have been reported to increase the risk of other infectious diseases, to our knowledge, an association between anti-TNF-alpha drugs and herpes simplex virus encephalitis has not been previously described.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adalimumab
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Adult
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Antibodies, Monoclonal / adverse effects
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Antibodies, Monoclonal / therapeutic use
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Antibodies, Monoclonal, Humanized
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Antirheumatic Agents / adverse effects*
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Antirheumatic Agents / therapeutic use
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Antiviral Agents / therapeutic use
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Encephalitis, Herpes Simplex / diagnosis
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Encephalitis, Herpes Simplex / drug therapy
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Encephalitis, Herpes Simplex / etiology*
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Female
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Herpesvirus 1, Human / isolation & purification
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Herpesvirus 2, Human / isolation & purification
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Humans
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Infliximab
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Rheumatic Diseases / complications*
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Rheumatic Diseases / drug therapy
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Risk Factors
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Treatment Outcome
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Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Antirheumatic Agents
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Antiviral Agents
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Tumor Necrosis Factor-alpha
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Infliximab
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Adalimumab