Guttiferones O and P, prenylated benzophenone MAPKAPK-2 inhibitors from Garcinia solomonensis

J Nat Prod. 2009 Sep;72(9):1699-701. doi: 10.1021/np900246t.

Abstract

Two prenylated benzophenones, guttiferones O (1) and P (2), were isolated from the stem bark of the Papua New Guinean plant Garcina solomonensis. The structures of these compounds and their relative configurations were determined by spectroscopic methods. Both compounds inhibited the phosphorylation of the synthetic biotinylated peptide substrate KKLNRTLSVA by the serine/threonine protein kinase MAPKAPK-2 with IC(50) values of 22.0 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzophenones / chemistry
  • Benzophenones / isolation & purification*
  • Benzophenones / pharmacology*
  • Garcinia / chemistry*
  • Humans
  • Intracellular Signaling Peptides and Proteins / antagonists & inhibitors*
  • Molecular Structure
  • Papua New Guinea
  • Plant Stems / chemistry
  • Plants, Medicinal / chemistry*
  • Protein Serine-Threonine Kinases / antagonists & inhibitors*

Substances

  • Benzophenones
  • Intracellular Signaling Peptides and Proteins
  • guttiferone O
  • guttiferone P
  • MAP-kinase-activated kinase 2
  • Protein Serine-Threonine Kinases