Virus-mediated mRNA decay by hyperadenylation

Genome Biol. 2009;10(8):234. doi: 10.1186/gb-2009-10-8-234. Epub 2009 Aug 11.

Abstract

Degradation of cellular mRNAs during Kaposi's sarcoma-associated herpesvirus infection is associated with hyperadenylation of transcripts and a relocalization of cytoplasmic poly(A)-binding proteins to the nucleus.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cell Nucleus / metabolism
  • Herpesvirus 8, Human / genetics
  • Herpesvirus 8, Human / metabolism*
  • Polyadenylation*
  • RNA Stability*
  • RNA, Messenger / metabolism
  • Sarcoma, Kaposi

Substances

  • RNA, Messenger