Abstract
Discorhabdin A (1) exhibits a strong cytotoxic activity in vitro, but it is difficult to synthesize and handle due to the instability of its highly strained N,S-acetal structure. We then designed the analogues of discorhabdin A which also have strong cytotoxic activity and stability. The synthesis and examination of the biological activity of various types of stable discorhabdin A oxa analogues (2) were achieved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetals
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Alkaloids / chemical synthesis*
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Alkaloids / chemistry
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Drug Screening Assays, Antitumor*
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Marine Biology*
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Oxytocin / analogs & derivatives*
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Oxytocin / chemical synthesis
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Oxytocin / chemistry
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Quinones / chemical synthesis*
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Quinones / chemistry
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Quinones / pharmacology
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / chemistry
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Spiro Compounds / pharmacology
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Structure-Activity Relationship
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Thiazepines / chemical synthesis*
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Thiazepines / chemistry
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Thiazepines / pharmacology
Substances
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Acetals
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Alkaloids
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Antineoplastic Agents
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Quinones
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Spiro Compounds
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Thiazepines
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discorhabdin A
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Oxytocin
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oxytocin, Asp(5)-