Objectives: The aim of this systematic review was to assess the internationally published survival and complication rates of implant-supported computer-aided designing (CAD) and computer-aided manufacturing (CAM)-fabricated restorations and to compare them with those of conventionally fabricated implant-supported restorations.
Methods: An electronic MEDLINE search was conducted to identify prospective and retrospective cohort studies on CAD-CAM fabricated implant-supported restorations with a mean follow-up time of at least 1 year. Failure and complication rates were evaluated and descriptive statistics were performed.
Results: An electronic MEDLINE search revealed four studies reporting on implant-supported CAD-CAM fabricated restorations. The cumulative 5-year survival rate of implants supporting full-arch-fixed dental prostheses (FDPs) ranged from 81.4% to 95.6%. Reported survival rates of implants supporting all-ceramic single crowns (SCs) were 100% [95% confidence interval (CI): 92.4-100]. The cumulative 5-year survival rate for full-arch FDPs ranged from 72.2% to 100%. Reported cumulative 5-year survival rates for all-ceramic SCs were 100% (95% CI: 92.4-100%). Technical complications were reported in two of the four selected studies and the estimated annual failure rate for chipping/fracture of the veneering material was 0.43 (95% CI: 0.06-3.06) for implant-supported all-ceramic SCs and 3.61 (95% CI: 2.05-6.36) for implant-supported FDPs.
Conclusions: Only a small number of clinical studies reporting on implant-supported CAD-CAM fabricated restorations exists which makes a scientifically valid comparison with conventionally fabricated restorations impossible.