The work presents a method of complex evaluation of homeostasis in patients with degenerative-dystrophic diseases of the hip joints after total endoprosthesis on the basis of mathematical integration of different laboratory indices allowing objective assessment of the state of the regulatory-metabolic status of the patient after operation of endoprosthesis, detection of disturbances of adaptive reaction to the operative trauma and, thus, prevision of the development of postoperative complications. The integral characterization is given of the periods of postaggression reaction using the proposed method. The interval of integral indices is determined which is characteristic of non-complicated postoperative period, depending on the time since the moment of operation.