19alpha-Hydroxy-3-oxo-ursa-1,12-dien-28-oic acid, an antiplasmodial triterpenoid isolated from Canthium multiflorum

Maminata Traoré-Coulibaly; Hanne L Ziegler; Carl Erik Olsen; Millogo-kone Hassanata; Guissou I Pierre; Odile G Nacoulma; T Rober Guiguemdé; S Brøgger Christensen

doi:10.1080/14786410802401481

19alpha-Hydroxy-3-oxo-ursa-1,12-dien-28-oic acid, an antiplasmodial triterpenoid isolated from Canthium multiflorum

Nat Prod Res. 2009;23(12):1108-11. doi: 10.1080/14786410802401481.

Authors

Maminata Traoré-Coulibaly¹, Hanne L Ziegler, Carl Erik Olsen, Millogo-kone Hassanata, Guissou I Pierre, Odile G Nacoulma, T Rober Guiguemdé, S Brøgger Christensen

Affiliation

¹ Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark.

PMID: 19662575
DOI: 10.1080/14786410802401481

Abstract

A bioactivity guided fractionation of roots of Canthium multiflorum led to the isolation of the new ursenoic acid derivative 19alpha-hydroxy-3-oxo-ursa-1,12-dien-28-oic acid (1), which showed antiplasmodial effect without inducing change of the shape of membranes of erythrocytes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimalarials / chemistry
Antimalarials / isolation & purification*
Antimalarials / pharmacology*
Erythrocytes / drug effects
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Plasmodium falciparum / drug effects*
Rubiaceae / chemistry*
Triterpenes / chemistry
Triterpenes / isolation & purification*
Triterpenes / pharmacology*

Substances

Antimalarials
Triterpenes