Abstract
Zerumbone (ZER), a sesquiterpene in Zingiber zerumbet Smith, has been implicated as a promising chemopreventive agent. Here we found that ZER suppressed expression of pro-inflammatory genes (COX-2 and iNOS) and induced detoxification genes (GSTP1 and NQO1) in RAW264.7 macrophages. Using the ZER-bound Sepharose gel, it appeared ZER was covalently bound to proteins, Keap1 and HuR, that play key roles in these molecular mechanisms.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / metabolism
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Anti-Inflammatory Agents / pharmacology
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Cell Line
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Chemoprevention
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Food*
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Gene Expression Regulation / drug effects
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Humans
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Macrophages / drug effects
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Macrophages / metabolism
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Mice
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Protein Binding
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Proteins / analysis*
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Proteins / chemistry
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Proteins / metabolism*
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Rats
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Sesquiterpenes / chemistry
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Sesquiterpenes / metabolism*
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Sesquiterpenes / pharmacology*
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Sulfhydryl Compounds / chemistry
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Zingiberaceae / chemistry*
Substances
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Anti-Inflammatory Agents
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Proteins
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Sesquiterpenes
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Sulfhydryl Compounds
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zerumbone