Abstract
In the present investigation, the anti-inflammatory activity of a polyphenolic enriched extract of Schima wallichii bark was evaluated in vitro using human peripheral blood mononuclear cells (PBMCs) and in vivo by carrageenan-induced paw oedema assay (acute study) and cotton pallet granuloma assay (chronic study). The extract exhibited significant inhibition of the production of tumour necrotic factor-α and interleukin-6 by PBMCs stimulated with lipopolysaccharide (LPS) in a concentration-dependent manner. The extract at the selected doses of 150 and 300 mg kg(-1) body weight p.o. exhibited significant dose-dependent anti-inflammatory responses, with 44.32 and 38.65% inhibition of inflammation in carrageenan-induced paw oedema and cotton pallet granuloma, respectively.
MeSH terms
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Adult
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Animals
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Anti-Inflammatory Agents / pharmacology
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Anti-Inflammatory Agents / therapeutic use
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Carrageenan / adverse effects
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Edema / chemically induced
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Edema / pathology
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Edema / prevention & control
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Granuloma / chemically induced
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Granuloma / pathology
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Granuloma / prevention & control
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Humans
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Inflammation / chemically induced
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Inflammation / drug therapy
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Interleukin-6 / antagonists & inhibitors
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Leukocytes, Mononuclear / immunology
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Lipopolysaccharides / pharmacology
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Plant Bark / chemistry*
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
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Rats
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Rats, Wistar
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Theaceae / chemistry*
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
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Young Adult
Substances
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Anti-Inflammatory Agents
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Interleukin-6
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Lipopolysaccharides
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Plant Extracts
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Tumor Necrosis Factor-alpha
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Carrageenan