The aim of this two-part treatment series is on the one hand to emphasize the difficulties a clinician is confronted with when planning complex cases, and on the other hand to reveal the rationale supporting the final treatment plan selection. Among the challenging cases to be considered are periodontal compromised rest dentitions requiring prosthodontic rehabilitation. For these patients the decision-making process deals with the indications and limitations of both the fields of fixed and removable prosthodontics. The first part of this article deals with the various prosthodontic treatment options, together with the advantages and disadvantages related to each one. This second part of the article presents the final treatment plan, the decision-making process, and the sequence of the treatment steps.