Downsizing of enzymes by chemical methods: arginine mimics with low pKa values increase the rates of hydrolysis of RNA model compounds
Angew Chem Int Ed Engl
.
2009;48(36):6722-5.
doi: 10.1002/anie.200900595.
Authors
N Johan V Lindgren
1
,
Lars Geiger
,
Jesus Razkin
,
Carsten Schmuck
,
Lars Baltzer
Affiliation
1
Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, 75123 Uppsala, Sweden.
PMID:
19655357
DOI:
10.1002/anie.200900595
No abstract available
MeSH terms
Amino Acid Sequence
Arginine / chemistry*
Catalytic Domain
Enzymes / chemistry*
Hydrogen-Ion Concentration
Hydrolysis
Models, Biological*
Molecular Mimicry
Molecular Sequence Data
Molecular Structure
RNA / chemistry*
Substances
Enzymes
RNA
Arginine