Bifunctional bisphosphonate complexes for the diagnosis and therapy of bone metastases

Chem Commun (Camb). 2009 Aug 28:(32):4847-9. doi: 10.1039/b908652h. Epub 2009 Jul 14.

Abstract

Easily synthesised and structurally well-defined novel imaging/therapeutic radiopharmaceutical agents for bone metastases are described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Neoplasms* / diagnosis
  • Bone Neoplasms* / diagnostic imaging
  • Bone Neoplasms* / drug therapy
  • Diphosphonates / therapeutic use*
  • Female
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mice
  • Mice, Inbred BALB C
  • Molecular Structure
  • Organotechnetium Compounds / chemistry*
  • Organotechnetium Compounds / therapeutic use
  • Radionuclide Imaging
  • Radiopharmaceuticals* / chemical synthesis
  • Radiopharmaceuticals* / chemistry
  • Radiopharmaceuticals* / therapeutic use
  • Rhenium / chemistry*

Substances

  • Diphosphonates
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • dithio-bisphosphine tc99m
  • Rhenium