Overexpression of Ycg1 or Ydr520c confers resistance to cadmium in Saccharomyces cerevisiae

Gi-Wook Hwang; Kanae Sasaki; Tsutomu Takahashi; Reiko Yamamoto; Akira Naganuma

doi:10.2131/jts.34.441

Overexpression of Ycg1 or Ydr520c confers resistance to cadmium in Saccharomyces cerevisiae

J Toxicol Sci. 2009 Oct;34(4):441-3. doi: 10.2131/jts.34.441.

Authors

Gi-Wook Hwang¹, Kanae Sasaki, Tsutomu Takahashi, Reiko Yamamoto, Akira Naganuma

Affiliation

¹ Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi 980-8578, Japan.

PMID: 19652468
DOI: 10.2131/jts.34.441

Abstract

We introduced a yeast open reading frame library into Saccharomyces cerevisiae strain BY4742 to search for genes whose overexpression conferred cadmium resistance to yeast, toward the goal of elucidating the mechanism of cadmium toxicity. As a result, we found that the overexpression of two newly identified genes, Ycg1 and Ydr520c, each conferred strong cadmium resistance to yeast.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cadmium / toxicity*
Cell Cycle Proteins / physiology*
Drug Resistance, Fungal / genetics*
Gene Expression Regulation, Fungal / genetics*
Open Reading Frames
Protein Serine-Threonine Kinases / physiology*
Saccharomyces cerevisiae / drug effects*
Saccharomyces cerevisiae / genetics*
Saccharomyces cerevisiae Proteins / physiology*

Substances

Cell Cycle Proteins
Saccharomyces cerevisiae Proteins
Cadmium
Protein Serine-Threonine Kinases
Sps1 protein, S cerevisiae