Abstract
Five new diketopiperazine alkaloids, brevicompanines D-H (3-7), together with two known analogs, allo-brevicompanine B (1) and fructigenine B (2), were isolated from a deep ocean sediment derived fungus Penicillium sp. Their structures were established by spectroscopic methods including 2D NMR and chiral HPLC analysis. Compounds 4 and 7 inhibited lipopolysaccharide (LPS)-induced nitric oxide production in BV2 microglial cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chromatography, High Pressure Liquid
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Diketopiperazines / chemistry
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Diketopiperazines / isolation & purification*
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Diketopiperazines / pharmacology
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Lipopolysaccharides / antagonists & inhibitors
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Lipopolysaccharides / pharmacology
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Magnetic Resonance Spectroscopy / standards
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Mice
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Microglia / cytology
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Microglia / drug effects
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Microglia / metabolism
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Nitric Oxide / biosynthesis
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Penicillium / chemistry*
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Reference Standards
Substances
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Diketopiperazines
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Lipopolysaccharides
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Nitric Oxide