Oleanane-type triterpene oligoglycosides with pancreatic lipase inhibitory activity from the pericarps of Sapindus rarak

Toshio Morikawa; Yuanyuan Xie; Yasunobu Asao; Masaki Okamoto; Chihiro Yamashita; Osamu Muraoka; Hisashi Matsuda; Yutana Pongpiriyadacha; Dan Yuan; Masayuki Yoshikawa

doi:10.1016/j.phytochem.2009.06.015

Oleanane-type triterpene oligoglycosides with pancreatic lipase inhibitory activity from the pericarps of Sapindus rarak

Phytochemistry. 2009 Jun;70(9):1166-1172. doi: 10.1016/j.phytochem.2009.06.015. Epub 2009 Jul 31.

Authors

Affiliations

¹ Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan.
² Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Wenhua Rd., Shenyang 110016, People's Republic of China.
³ Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.
⁴ Faculty of Science and Technology, Rajamangala University of Technology, Srivijaya, Thungyai, Nakhonsithammarat 80240, Thailand.
⁵ School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Wenhua Rd., Shenyang 110016, People's Republic of China.
⁶ Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan; Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan. Electronic address: myoshika@mb.kyoto-phu.ac.jp.

PMID: 19647280
DOI: 10.1016/j.phytochem.2009.06.015

Abstract

The methanolic extract from the pericarps of Sapindus rarak DC. was found to show pancreatic lipase inhibitory activity (IC50=ca. 614 microg/mL). From the extract, oleanane-type triterpene oligoglycosides, rarasaponins I-III (1-3), and raraoside A (4), were isolated together with 13 known saponins and four known sesquiterpene glycosides. Among them, several saponin constituents including rarasaponins I (1, IC50=131microM) and II (2, 172microM), and raraoside A (4, 151microM) inhibited pancreatic lipase activity, which were stronger than that of theasaponin E(1) (270microM).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Glycosides / chemistry
Glycosides / isolation & purification*
Glycosides / pharmacology*
Inhibitory Concentration 50
Lipase / antagonists & inhibitors*
Molecular Structure
Oleanolic Acid / analogs & derivatives*
Oleanolic Acid / chemistry
Oleanolic Acid / isolation & purification*
Oleanolic Acid / pharmacology*
Pancreas / enzymology*
Plants, Medicinal / chemistry*
Sapindus / chemistry*
Saponins / pharmacology
Swine

Substances

Glycosides
Saponins
raraoside A
rarasaponin I
theasaponin E1
Oleanolic Acid
Lipase