Design, synthesis and analgesic properties of novel conformationally-restricted N-acylhydrazones (NAH)

Bioorg Med Chem Lett. 2009 Sep 1;19(17):4963-6. doi: 10.1016/j.bmcl.2009.07.075. Epub 2009 Jul 18.

Authors

Arthur E Kümmerle¹, Marina M Vieira, Martine Schmitt, Ana L P Miranda, Carlos A M Fraga, Jean-Jacques Bourguignon, Eliezer J Barreiro

Affiliation

¹ Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, RJ, Brazil.

PMID: 19646868
DOI: 10.1016/j.bmcl.2009.07.075

Abstract

A set of six azaheterocycles were designed as conformationally-constrained N-acylhydrazones and tested as analgesics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Analgesics / chemical synthesis*
Analgesics / chemistry
Analgesics / pharmacology
Animals
Drug Design
Hydrazones / chemical synthesis*
Hydrazones / chemistry
Hydrazones / pharmacology
Mice
Molecular Conformation
Stereoisomerism
Structure-Activity Relationship

Substances

Analgesics
Hydrazones