Abstract
A series of novel 1-(4-methylcoumarinyl-7-oxyacetyl)-3,5-dimethyl-4(arylazo)pyrazoles and 1-(4-methylcoumarinyl-7-oxyacetyl)-3-methyl-4-(substituted phenyl) hydrazono-2-pyrazolin-5-ones were synthesised and evaluated for antibacterial and antioxidant activities. Compounds 3b, 3g, 5b, 5d and 5g showed good antibacterial activity and compound 5e was found to be the most active antioxidant in the series, and thus represent a new class of promising lead compounds.
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Antioxidants / chemistry*
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Antioxidants / pharmacology*
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Bacillus subtilis / drug effects
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Coumarins / chemistry
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Coumarins / pharmacology
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / pharmacology
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Pyrazoles / chemistry*
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Pyrazoles / pharmacology*
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Pyrazolones / chemistry
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Pyrazolones / pharmacology
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Staphylococcus aureus / drug effects
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antioxidants
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Coumarins
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Free Radical Scavengers
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Pyrazoles
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Pyrazolones
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coumarin