Calcific uremic arteriolopathy (CUA) is a rare syndrome characterized by medial calcification of the small arteries and ischemia of the subcutaneous tissue that progresses to non-healing ulcers and gangrene. It is common in patients with end-stage renal disease (ESRD), associated with high morbidity and mortality, and there is no standard treatment at the present time. We report a case of CUA developing in a 70-year-old woman on dialysis, with a normal plasma concentration of parathyroid hormone but a body mass index of 40 kg/m(2) and receiving oral anticoagulant therapy. She was successfully treated with a multidisciplinary approach focused on medical and surgical therapy.