Abstract
Simvastatin significantly inhibited the proliferation of endometriotic stromal cells, attenuated the collagen gel contraction mediated by these cells, and suppressed endometriotic stromal cell attachment to collagen fibers. Simvastatin is considered to be a promising agent for the treatment of endometriosis-associated fibrosis, which is among the major pathologies caused by endometriosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Division / drug effects
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Cells, Cultured
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Collagen / metabolism
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Endometriosis / drug therapy*
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Endometriosis / pathology*
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Female
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Fibrosis
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology
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In Vitro Techniques
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Simvastatin / pharmacology*
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Stromal Cells / drug effects*
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Stromal Cells / metabolism
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Stromal Cells / pathology*
Substances
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Collagen
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Simvastatin