Abstract
The anti-AIDS drug AZT was covalently attached to the recently reported sorbitol-G8 transporter, and the conjugate was found to target mitochondria in HeLa cells and readily cross the blood-brain barrier (BBB) to gain access into the mouse brain, suggesting the potential of these molecular transporters as practical central nervous system (CNS) delivery vectors.
MeSH terms
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Animals
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / metabolism
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Blood-Brain Barrier*
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HeLa Cells
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Humans
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Mice
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Microscopy, Confocal
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Mitochondria / drug effects*
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Molecular Structure
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Permeability
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Zidovudine / chemical synthesis*
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Zidovudine / chemistry
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Zidovudine / metabolism
Substances
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Anti-HIV Agents
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Zidovudine