First description of NOD2 variant associated with defective neutrophil responses in a woman with granulomatous mastitis related to corynebacteria

J Clin Microbiol. 2009 Sep;47(9):3034-7. doi: 10.1128/JCM.00561-09. Epub 2009 Jul 29.

Abstract

We report the first case of granulomatous mastitis due to Corynebacterium kroppenstedtii linked to strongly impaired neutrophil responses to Nod2 agonist and a single nucleotide polymorphism within the NOD2 gene (SNP13 [Leu1007fsinsC]) in a heterozygous state. These findings provided the first demonstration of impaired Nod2 function associated with corynebacterial infection.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Breast / microbiology
  • Breast / pathology
  • Corynebacterium Infections / immunology*
  • Female
  • Heterozygote
  • Humans
  • Mastitis / genetics*
  • Mastitis / immunology*
  • Mastitis / microbiology
  • Molecular Sequence Data
  • Neutrophils / immunology*
  • Nod2 Signaling Adaptor Protein / genetics*
  • Polymorphism, Genetic*

Substances

  • NOD2 protein, human
  • Nod2 Signaling Adaptor Protein

Associated data

  • GENBANK/GQ244303