Corallolides A and B: bioactive diterpenes featuring a novel carbon skeleton

Org Lett. 2009 Aug 20;11(16):3786-9. doi: 10.1021/ol901577a.

Abstract

Corallolides A (1) and B (2) are naturally occurring diterpenes isolated from the Caribbean gorgonian octocoral Pseudopterogorgia bipinnata collected near Providencia Island, Colombia. Their tricyclic structures are based on a uniquely substituted bicyclo[9.2.1]tetradecane ring system that was established through detailed spectroscopic analysis. Compounds 1 and 2 were shown to exhibit antiparasitic and antituberculosis activity, respectively.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antimalarials / chemistry
  • Antimalarials / isolation & purification*
  • Antimalarials / pharmacology*
  • Antitubercular Agents / chemistry
  • Antitubercular Agents / isolation & purification*
  • Antitubercular Agents / pharmacology*
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology*
  • Drug Screening Assays, Antitumor
  • Humans
  • Molecular Structure
  • Mycobacterium tuberculosis / drug effects*
  • Plasmodium falciparum / drug effects*

Substances

  • Antimalarials
  • Antitubercular Agents
  • Diterpenes
  • corallolide A
  • corallolide B