Abstract
Corallolides A (1) and B (2) are naturally occurring diterpenes isolated from the Caribbean gorgonian octocoral Pseudopterogorgia bipinnata collected near Providencia Island, Colombia. Their tricyclic structures are based on a uniquely substituted bicyclo[9.2.1]tetradecane ring system that was established through detailed spectroscopic analysis. Compounds 1 and 2 were shown to exhibit antiparasitic and antituberculosis activity, respectively.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Anthozoa / chemistry*
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology*
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Antitubercular Agents / chemistry
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Antitubercular Agents / isolation & purification*
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Antitubercular Agents / pharmacology*
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Molecular Structure
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Mycobacterium tuberculosis / drug effects*
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Plasmodium falciparum / drug effects*
Substances
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Antimalarials
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Antitubercular Agents
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Diterpenes
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corallolide A
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corallolide B