Backbone assignment of osteopontin, a cytokine and cell attachment protein implicated in tumorigenesis

Biomol NMR Assign. 2008 Jun;2(1):29-31. doi: 10.1007/s12104-007-9076-2. Epub 2008 Jan 18.

Abstract

OPN is an RGD-containing protein overexpressed in cells transformed by v-myc and v-mil(raf) oncogenes. Here we report the resonance assignment of recombinant quail OPN and provide NMR evidence that quail OPN is an intrinsically unstructured protein in solution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Carbon Isotopes / chemistry
  • Cell Adhesion Molecules / chemistry*
  • Cytokines / chemistry*
  • Magnetic Resonance Spectroscopy / methods*
  • Molecular Sequence Data
  • Molecular Weight
  • Neoplasms / metabolism
  • Nitrogen Isotopes / chemistry
  • Osteopontin / chemistry*
  • Protons
  • Quail / metabolism*

Substances

  • Carbon Isotopes
  • Cell Adhesion Molecules
  • Cytokines
  • Nitrogen Isotopes
  • Protons
  • Osteopontin