Convenient synthesis of Ibuprofen and naproxen aminoacyl, dipeptidoyl and ester derivatives

Alan R Katritzky; Davit Jishkariani; Tamari Narindoshvili

doi:10.1111/j.1747-0285.2009.00811.x

Convenient synthesis of Ibuprofen and naproxen aminoacyl, dipeptidoyl and ester derivatives

Chem Biol Drug Des. 2009 Jun;73(6):618-26. doi: 10.1111/j.1747-0285.2009.00811.x.

Authors

Alan R Katritzky¹, Davit Jishkariani, Tamari Narindoshvili

Affiliation

¹ Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu

PMID: 19635053
DOI: 10.1111/j.1747-0285.2009.00811.x

Abstract

DL-Ibuprofen and L-naproxen were coupled with amino acids and other bioactive compounds to provide ibuprofen and naproxen bioconjugates in 61-95% yield as prodrugs or potential drug candidates.

MeSH terms

Amino Acids / chemistry
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Dipeptides / chemistry
Esters
Ibuprofen / analogs & derivatives*
Ibuprofen / chemical synthesis
Ibuprofen / chemistry
Naproxen / analogs & derivatives*
Naproxen / chemical synthesis
Naproxen / chemistry
Prodrugs / chemical synthesis*
Prodrugs / chemistry
Stigmasterol / chemistry

Substances

Amino Acids
Anti-Inflammatory Agents, Non-Steroidal
Dipeptides
Esters
Prodrugs
Naproxen
Stigmasterol
Ibuprofen